Fundamentals of Molecular Biology - V.I. Rezyapkin 2009



Introduction

Nucleic Acids

Composition of Nucleic Acids

Primary Structure of Nucleic Acids

Secondary Structure of DNA

Physicochemical Properties of DNA

Organization of Eukaryotic DNA

Spatial Organization of RNA

Replication

Proteins and Enzymes Involved in DNA Replication

General Characteristics of Replication

The mechanism of replication in E. coli

Eukaryotic chromosome replication

Telomere Synthesis

DNA Repair

DNA Lesions

Direct Repair

Excision Repair

Repair of DNA Replication Errors

Recombinational (Postreplication) DNA Repair

SOS Response

Transcription

Prokaryotic Transcription

Eukaryotic Transcription

Non-template RNA synthesis

RNA, RNA Processing

Messenger RNA

rRNA. Ribosomes

tRNA

RNA Processing

mRNA Processing

tRNA Processing

rRNA Processing

Translation

Properties of the Genetic Code

Wobble Hypothesis

Stages of Protein Biosynthesis

Molecular Organization of Genes

Regulation of Gene Expression

Regulation of Gene Expression at the Level of DNA Organization

Regulation of Gene Expression at the Transcriptional Level

Regulation of Gene Expression at the RNA Processing Level

Regulation at the Level of mRNA Degradation

Regulation of Gene Expression at the Translational Level

Global Regulation of Translation in Eukaryotes

Translation Ambiguity

Post-Translational Protein Modification

Genome Rearrangements

Homologous Recombination

Site-Specific Recombination

Transpositions

Illegitimate Recombination

DNA Rearrangement in Yeast

DNA Rearrangements in Spirotrichous Ciliates

Genome rearrangements

Chromatin diminution

Immunoglobulin gene rearrangements

Genome Rearrangements

Amplification

Lysogeny

Transduction

Mobile Genetic Elements

Mobile Genetic Elements in Prokaryotes

Transposons

Plasmids

Mobile Genetic Elements in Eukaryotes

Long Terminal Repeat (LTR) Retrotransposons

Non-LTR Retrotransposons

Retrotransposons

Genome Organization

Organization of the Viral Genome

DNA-Containing Viruses

Replication of Genomes in DNA-Containing Viruses

Integration of the Viral Genome into the Cellular Genome

Transcription of DNA-Containing Virus Genomes

RNA-Containing Viruses

Transcription and Replication of Single-Stranded (+)RNA Genomes

Transcription and Replication of Single-Stranded (-)RNA Genomes

RNA Replication of Viroids

Organization of Genomes

Life Cycle of Retroviruses

Genome Organization

Prokaryotic Genome Organization

Eukaryotic Genome Organization

The Human Genome

Mitochondrial Genome

References