Fundamentals of Molecular Biology - V.I. Rezyapkin 2009

Genome Rearrangements
Illegitimate Recombination

Illegitimate recombination occurs between non-homologous DNA molecules without the involvement of Site-Specific Recombination or transposition mechanisms. As a result of illegitimate recombination, the ends of non-homologous DNA molecules are rejoined. Examples of illegitimate recombination include the integration into a chromosome of DNA introduced into a Cell Nucleus via microinjection, and the capture of cellular genes by a retrovirus during its excision from the chromosome. Illegitimate recombination also plays a certain role in Immunoglobulin Gene rearrangements. The mechanisms of illegitimate recombination remain insufficiently studied to date.



Last update: 12/08/2026

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