IMMUNOLOGY - Roitt I. - Mir 2000

Preface

List of abbreviations. Icon symbols

Chapter 1. Overview of the Immune System

  ACQUIRED AND INNATE IMMUNITY

  CELLS OF THE IMMUNE SYSTEM

  SOLUBLE MEDIATORS OF IMMUNITY

  ANTIGENS

  IMMUNE RESPONSE

  INFLAMMATION

  DEFENSE AGAINST EXTRACELLULAR AND INTRACELLULAR INFECTIONS

  VACCINATION

  IMMUNOPATHOLOGY

Chapter 2. Cells Mediating the Immune Response

  LYMPHOID CELLS

  MONONUCLEAR PHAGOCYTES

  ANTIGEN-PRESENTING CELLS

  POLYMORPHONUCLEAR GRANULOCYTES, MAST CELLS, AND PLATELETS

Chapter 3. The Lymphoid System

  LYMPHOID TISSUES ARE PART OF PRIMARY AND SECONDARY LYMPHOID ORGANS AND STRUCTURES

  PRIMARY LYMPHOID ORGANS

  SECONDARY LYMPHOID ORGANS AND STRUCTURES

  LYMPHOCYTE CIRCULATION

Chapter 4. Complement

  INTRODUCTION

  COMPLEMENT ACTIVATION

  COMPLEMENT RECEPTORS

  BIOLOGICAL EFFECTS OF COMPLEMENT

Chapter 5. Cell Migration and Inflammation

  CELL MIGRATION

  CELL ADHESION MOLECULES

  MECHANISMS OF CELL MIGRATION

  INFLAMMATION

Chapter 6. Antibodies and Their Cellular Receptors

  IMMUNOGLOBULINS: A UNIQUE PROTEIN FAMILY

  ANTIBODY STRUCTURE

  ANTIBODY MOLECULES EXHIBIT ISOTYPIC, ALLOTYPIC, AND IDIOTYPIC VARIATIONS IN AMINO ACID SEQUENCE

  EFFECTOR FUNCTIONS OF ANTIBODIES

  CELLULAR RECEPTORS FOR ANTIBODIES

  ANALYSIS OF ANTIBODY STRUCTURE AND FUNCTION

Chapter 7. T-Cell Antigen-Recognizing Receptors and MHC Molecules

  T-CELL RECEPTORS

  MAJOR HISTOCOMPATIBILITY COMPLEX (MHC) ANTIGENS

  GENOMIC ORGANIZATION OF THE MHC

Chapter 8. Sources of Diversity in Antigen-Recognizing Structures

  THEORIES OF ANTIBODY FORMATION

  IMMUNOGLOBULIN VARIABILITY

  Ig GENE RECOMBINATION

  SOMATIC MUTAGENESIS

  IMMUNOGLOBULIN DIVERSITY IN OTHER VERTEBRATES

  HEAVY CHAIN CONSTANT REGION GENES

  REGULATION OF IMMUNOGLOBULIN SYNTHESIS

  GENES OF THE ANTIGEN-RECOGNIZING T-CELL RECEPTOR

  SCALE OF DIVERSITY

Chapter 9. Antigen Recognition

  ANTIBODY-ANTIGEN BINDING

  ANTIBODY SPECIFICITY AND AFFINITY

  ANTIGEN STRUCTURE

  T-CELL ANTIGEN RECOGNITION

  ANTIGEN PROCESSING AND PRESENTATION

  FORMATION AND STRUCTURE OF THE ANTIGENIC PEPTIDE-MHC MOLECULE COMPLEX

Chapter 10. Cell-Mediated Immune Responses

  CYTOKINES AND THEIR CELLULAR RECEPTORS

  T-CELL-INDEPENDENT DEFENSE MECHANISMS

  T-CELL-DEPENDENT CELLULAR IMMUNE RESPONSE

  T-CELL AND NK-CELL CYTOTOXICITY

  ROLE OF MACROPHAGES IN THE IMMUNE RESPONSE

  GRANULOMA FORMATION

  IMMUNOPATHOLOGY

  CYTOKINE NETWORK INTERACTIONS

Chapter 11. Cellular Interactions in Humoral Immune Responses

  ANTIGEN PRESENTATION TO T CELLS

  B- AND T-CELL INTERACTIONS

  INTRACELLULAR SIGNALS DURING LYMPHOCYTE ACTIVATION

  EFFECTS OF CYTOKINES ON B AND T CELLS

  HUMORAL IMMUNE RESPONSE IN VIVO

Chapter 12. Ontogenetic Development of the Immune System

  MYELOID CELLS

  COMPLEMENT SYSTEM

  LYMPHOID CELLS

  DIVERSITY OF ANTIBODY SPECIFICITIES

  DIVERSITY OF ANTIBODY ISOTYPES

  GENERATION OF MEMORY B CELLS

Chapter 13. Regulation of the Immune Response

  ANTIGENS AS IMMUNOREGULATORY FACTORS

  ANTIGEN-PRESENTING CELLS

  REGULATORY EFFECTS OF ANTIBODIES

  ROLE OF LYMPHOCYTES IN IMMUNOREGULATION

  IDIOTYPIC MODULATION OF THE IMMUNE RESPONSE

  NEUROENDOCRINE REGULATION OF THE IMMUNE RESPONSE

  GENETIC REGULATION OF THE IMMUNE RESPONSE

Chapter 14. Immunological Tolerance

  INTRODUCTION

  EXPERIMENTAL INDUCTION OF TOLERANCE

  CENTRAL THYMIC TOLERANCE TO AUTOANTIGENS

  PERIPHERAL, OR POST-THYMIC, TOLERANCE TO SELF-ANTIGENS

  B-CELL TOLERANCE TO SELF-ANTIGENS

  ARTIFICIALLY INDUCED TOLERANCE IN VITRO

  ARTIFICIALLY INDUCED TOLERANCE IN VIVO

  INDUCTION OF TOLERANCE AS A POTENTIAL THERAPEUTIC APPROACH

Chapter 15. Evolution of the Immune System

  IMMUNITY IN INVERTEBRATES

  IMMUNITY IN VERTEBRATES

  LYMPHOMYELOID TISSUES IN LOWER VERTEBRATES

  AMPHIBIANS AS A MODEL FOR STUDYING IMMUNE ONTOGENY

Chapter 16. Antiviral Immunity

  TYPES OF VIRAL INFECTIONS

  INNATE ANTIVIRAL IMMUNITY

  T- AND B-CELL-MEDIATED DEFENSE MECHANISMS

  STRATEGIES OF VIRAL EVASION FROM IMMUNOLOGICAL CONTROL

  IMMUNOPATHOLOGY

Chapter 17. Immunity to Bacterial and Fungal Infections

  IMMUNITY TO BACTERIA

  IMMUNITY TO FUNGI

Chapter 18. Immunity to Parasitic Infections

  KEY FEATURES OF PARASITIC INFECTIONS

  EFFECTOR MECHANISMS

  T LYMPHOCYTES PLAY A MAJOR ROLE IN THE DEVELOPMENT OF IMMUNITY

  MECHANISMS OF EVASION FROM THE IMMUNE RESPONSE

  IMMUNOPATHOLOGICAL CONSEQUENCES OF PARASITIC INFECTIONS

  VACCINES

Chapter 19. Vaccination

  ANTIGENIC PREPARATIONS USED AS VACCINES

  VACCINE EFFICACY

  VACCINE SAFETY

  COST OF VACCINATION

  MODERN VACCINES

  ADJUVANTS

  PASSIVE IMMUNIZATION

  NON-SPECIFIC IMMUNOTHERAPY

  APPLICATION OF VACCINES IN CANCER THERAPY

  CONTRACEPTIVE VACCINES

Chapter 20. Tumor Immunology

  TUMOR AS A TISSUE TRANSPLANT

  IMMUNOLOGICAL SURVEILLANCE

  TUMOR-ASSOCIATED ANTIGENS RECOGNIZED BY IMMUNE CELLS

  TUMOR-ASSOCIATED ANTIGENS RECOGNIZED BY ANTIBODIES

  IMMUNE RESPONSE TO HUMAN TUMORS AND MECHANISMS OF TUMOR EVASION

  IMMUNODIAGNOSTICS

  IMMUNOTHERAPY

Chapter 21. Primary Immunodeficiency

  B-CELL DEFICIENCIES

  T-CELL DEFICIENCIES

  COMPLEMENT SYSTEM PROTEIN DEFICIENCIES

  PHAGOCYTIC CELL DEFECTS

Chapter 22. Secondary Immunodeficiency

  DRUG-INDUCED IMMUNODEFICIENCIES

  NUTRITION AND IMMUNE REACTIVITY

  AIDS

Chapter 23. Hypersensitivity - Type I

  TYPE I (IMMEDIATE) HYPERSENSITIVITY

  IMMUNOGLOBULIN E

  GENETICS OF HUMAN ALLERGIC REACTIONS

  GENES REGULATING ALLERGEN-SPECIFIC RESPONSES ARE LINKED TO HLA

  MAST CELLS

  SKIN REACTIONS

  BRONCHIAL REACTIONS

  FACTORS DETERMINING THE DEVELOPMENT OF ALLERGY

  ALLERGIC BREAKTHROUGH HYPOTHESIS

  DESENSITIZATION

  THE BENEFICIAL ROLE OF IgE

Chapter 24. Type II Hypersensitivity

  MECHANISMS OF TISSUE INJURY

  REACTIONS DIRECTED AGAINST BLOOD CELLS

  REACTIONS DIRECTED AGAINST TISSUE ANTIGENS

Chapter 25. Type III Hypersensitivity

  TYPES OF IMMUNE COMPLEX DISEASES

  MECHANISMS OF TYPE III HYPERSENSITIVITY

  EXPERIMENTAL MODELS OF IMMUNE COMPLEX DISEASES

  COMPLEX PERSISTENCE

  TISSUE DEPOSITION OF COMPLEXES

  DETECTION OF IMMUNE COMPLEXES

Chapter 26. Type IV Hypersensitivity

  CONTACT HYPERSENSITIVITY

  TUBERCULIN-TYPE HYPERSENSITIVITY

  GRANULOMATOUS HYPERSENSITIVITY

  CELLULAR REACTIONS IN TYPE IV HYPERSENSITIVITY

  DISEASES ASSOCIATED WITH TYPE IV GRANULOMATOUS HYPERSENSITIVITY REACTIONS

Chapter 27. Transplantation and Rejection

  TRANSPLANTATION BARRIER

  HISTOCOMPATIBILITY ANTIGENS

  LAWS OF TRANSPLANTATION

  ROLE OF T LYMPHOCYTES IN GRAFT REJECTION

  DYNAMICS OF REJECTION

  PREVENTION OF GRAFT REJECTION

Chapter 28. Autoimmune Processes and Autoimmune Diseases

  LINK BETWEEN AUTOIMMUNITY AND PATHOLOGY

  SPECTRUM OF AUTOIMMUNE DISEASES

  GENETIC FACTORS

  PATHOGENESIS

  ETIOLOGY

  DIAGNOSTIC AND PROGNOSTIC SIGNIFICANCE OF AUTOANTIBODIES

  TREATMENT

Chapter 29. Immunological Methods

  ANTIGEN-ANTIBODY INTERACTION

  PRODUCTION OF PURIFIED ANTIBODIES

  DETERMINATION OF COMPLEMENT

  ISOLATION OF LYMPHOCYTE POPULATIONS

  METHODS FOR DETECTING EFFECTOR CELLS

  TRANSGENIC ANIMALS AND TARGETED GENE DELIVERY

Appendices

  Appendix I: HLA Specificities

  Appendix II: CD Markers

  Appendix III: Major Cytokines

Glossary of Terms