Glycoproteins - Hughes R. 1985

Translator's Note

Introduction

Structure

Sequence Determination

Enzymatic Analysis

Structure of N-glycans

Ovalbumin

Immunoglobulins

Orosomucoid

Endoglycosidases

Structure of O-glycans

Secrets of the glycoprotein nature (mucins)

Blood Group Antigens

Membrane Glycoproteins: General Concepts

Glycophorin

Membrane glycoproteins. General concepts

Erythrocyte membranes

Biosynthesis

Glycosyltransferases

Donors

Assembly of N-glycans

Carrier lipids

Processing

Termination reactions

O-glycan assembly

Localization of the glycosylation process within the cell

Control of glycan biosynthesis

Metabolic control

Genetic control

Glycosyltransferase modulators

Functions

Polypeptide processing

Lectins: Carbohydrate-Binding Proteins

General Properties

Specificity

Toxic Lectins

Lectin-Resistant Cells

Intracellular transport of glycoproteins

Blocking of glycosylation

Lysosomal enzyme cycle

Catabolism and Clearance

Soluble Glycoproteins

Cells

Cell Adhesion

Cell-to-Cell Adhesion

Cell adhesion

Attachment of cells to the substrate

Appendix