Biochemistry in Tables, Schemes and Graphs - S.D. Zhamsaranova 2009

Lipid Metabolism and Functions
Eicosanoids

BIOLOGICALLY ACTIVE SUBSTANCES synthesized by most Cells from 20-carbon polyenoic Fatty acids.

Eicosanoids are divided into the following classes:

a) Prostaglandins (including prostacyclins);

б) thromboxanes;

в) Leukotrienes.

Class="center">BIOLOGICAL EFFECTS OF MAJOR EICOSANOID TYPES

Eicosanoids

Primary site of synthesis

Main biological effect

РGЕ2

Most Tissues, especially the Kidneys

Relaxes smooth Muscle, vasodilation, initiates labor

PGF2a

Most tissues

Contracts smooth muscle, vasoconstriction, bronchoconstriction, stimulates uterine contractions

РGI2

Heart, vascular endothelial cells

Inhibits platelet aggregation, vasodilation, increases cAMP production in target cells

TXA2

Platelets

Stimulates platelet aggregation, vasoconstriction, decreases cAMP production in cells

TXB2

Platelets

Vasoconstriction

LTB4

White Blood Cells, epithelial cells

Stimulates leukocyte chemotaxis and aggregation

LTC4→LTD4

White blood cells, alveolar macrophages

Stimulates vasodilation, increases vascular permeability, induces bronchoconstriction. Major components slowly reacting


Last update: 06/08/2026

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