Obstetrics and Gynecology - A.M. Hromova 2000

Background and precancerous conditions of the female reproductive organs
Endometrial hyperplastic processes
Etiology and pathogenesis

Endometrial Hyperplastic Processes represent one of the most pressing issues in gynecology. Their incidence increases significantly during the period of age-related hormonal shifts in perimenopause. The complexity of this problem stems from the fact that hyperplasia of the uterine mucosa can be a manifestation of numerous pathological conditions in the female body.

Balanced hormonal action mediated via cytoplasmic and nuclear receptors ensures physiological cyclic Changes in the uterine mucosa. Alterations in a woman's hormonal status resulting from an imbalance in the FSH/LH ratio (absolute or relative LH deficiency) may lead to abnormal tissue growth.

Proliferative effects are induced not only by classical estrogens (estradiol, estrone, estriol) but also by phenol Steroids produced in the Ovaries and Adrenal Glands, particularly in the postmenopausal period. Impaired hormone METABOLISM in The Liver and gastrointestinal tract, disturbances in Lipid Metabolism, thyroid dysfunction, and compromised Immunity also contribute to The Development of hyperplastic processes.

The medical history of patients may include episodes of Dysfunctional Uterine Bleeding at various stages of life, as well as severe stressful events, which underscores The Role of the Central Nervous system in the Pathogenesis of this condition.

During Puberty, endometrial hyperplasia is predominantly triggered by anovulation of the follicular atresia type, accompanied by prolonged endometrial stimulation by low doses of estrogens and a progestogen-deficient state. In some cases, hyperplastic processes may develop even in the presence of undisturbed hormonal ratios.



Last update: 08/08/2026

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