MEDICAL BIOLOGY, HUMAN ANATOMY, PHYSIOLOGY AND PATHOLOGY - Y.I. Fedoniuk 2010

ANATOMY, PHYSIOLOGY, PATHOLOGY

CHAPTER 7. THE NUTRITIONAL PROCESS AND ITS PATHOLOGY

PATHOLOGY OF THE DIGESTIVE SYSTEM

PANCREATIC PATHOLOGY

2. PANCREATIC CANCER

Pancreatic carcinoma is most prevalent in men aged 60 to 70 and predominantly affects the HEAD of the Pancreas, and less frequently the body and tail. The tumor site typically presents as an indurated mass with a loss of the normal lobular architecture on cross-section. Histologically, the neoplasm is an adenocarcinoma originating from the pancreatic ducts, or a tumor of the glandular parenchyma. In both cases, Connective Tissue proliferation is typically observed.

Carcinoma of the body and tail of the pancreas often remains asymptomatic for a long period. Cancer of the head may invade the duodenum and obstruct the Bile duct, resulting in biliary obstruction and jaundice. It can also invade the portal vein and metastasize to the Liver.

Insulomas are tumors originating from pancreatic islet Cells (insulocytes). They can be either benign or malignant. In most cases, insulomas lead to excessive Insulin levels. The 5-year survival rate for insulomas is approximately 40 %.



Last update: 08/08/2026

Editorial and Educational Adaptation: This material has been compiled based on the primary/original source text. The project team performed an editorial review, corrected technical inaccuracies, structured sections, and adapted the content for an educational format.

What was processed:

  • elimination of formatting defects (OCR errors, structural breaks, corrupted characters);
  • editorial organization of content;
  • standardization of terminology in accordance with academic sources;
  • verification of factual statements against the original source text.

All mentions of the author, publication year, and origin of the primary text have been preserved in accordance with the source.