Intensive Care of Acute Poisoning - A. V. Hovenko 2010

General Characteristics of Acute Poisoning
Exotoxic Shock
Hemostatic Disorders in Exotoxic Shock

Disorders of the hemostatic system in acute poisonings are referred to as "toxic coagulopathy." It is a type of thrombohemorrhagic syndrome manifested by hypercoagulation, consumption coagulopathy, and Fibrinolysis.

Poisoning by any substance leads to pathological Changes in the Blood Coagulation SYSTEM, creating conditions for The Development of toxic coagulopathy syndrome. At the initial stage of its progression, microcirculatory disorders, hypovolemia, and acidosis play a crucial role. In addition, certain poisonings (e.g., with acetic essence or dichloroethane) cause severe alterations in capillary permeability driven by the direct Toxic Effect of the poison on the Skin and vascular endothelium.

Hypercoagulation as a manifestation of toxic coagulopathy is caused by damage to the Central Nervous system and respiratory Organs, metabolic acidosis, hemolysis, blockade of the reticuloendothelial system, and Impairment of the Liver and Kidneys (B. A. Kudryashov, 1975). The onset of hypercoagulation triggers the consumption and retention of blood clotting factors—such as fibrinogen and platelets—by the reticuloendothelial system, resulting in multiple thromboses and secondary fibrinolysis (R. Hardaway, 1969). Hypercoagulation exacerbates microcirculatory disturbances in the Lungs, liver, and kidneys.



Last update: 08/08/2026

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