MEDICAL BIOLOGY, ANATOMY, HUMAN PHYSIOLOGY AND PATHOLOGY - Ya.I. Fedonyuk 2010

BIOLOGY

SECTION 1. BIOLOGICAL FOUNDATIONS OF HUMAN VITAL ACTIVITY

1.3. MOLECULAR-GENETIC AND CELLULAR LEVELS OF LIFE ORGANIZATION

1.3.3. Hereditary apparatus of eukaryotic cells and its functioning - molecular level

The Central Dogma of Molecular Biology

The concept that Genetic information is stored in DNA, transmitted from Cell to Cell across generations through Replication, and expressed during METABOLISM/35.html">Protein Biosynthesis via transfer from DNA to mRNA (Transcription) and subsequently from mRNA to protein (Translation), is known as the central dogma of molecular biology. It was proposed in 1958 by F. Crick and can be represented by the following scheme:

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In 1970, American geneticists H. Temin and D. Baltimore discovered an enzyme in RNA-containing Oncogenic Viruses that catalyzes DNA Synthesis using an mRNA template (reverse transcription). This enzyme was named RNA-dependent DNA polymerase, or Reverse Transcriptase - recombinase (from Latin reversio - return). Following the discovery of reverse transcription, the scheme of the central dogma of molecular biology took on the following form:



Last update: 08/08/2026

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