Human Biochemistry Volume 1 - Murray R. 1993

Bioenergetics and Carbohydrate and Lipid Metabolism
Oxidative Phosphorylation and Mitochondrial Transport Systems
Biomedical Significance

Oxidative Phosphorylation enables aerobic organisms to capture a significant fraction of the potential Free energy derived from substrate oxidation. A plausible mechanism for Oxidative phosphorylation is provided by the chemiosmotic theory. A number of drugs (such as amobarbital) and poisons (cyanide, carbon monoxide) inhibit oxidative phosphorylation, typically with fatal consequences. Oxidative phosphorylation is such a vital process that any disruption to its normal course is incompatible with life. This explains why only a small number of Genetic Disorders affecting this system have been identified.



Last update: 06/08/2026

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