Protein Chemistry. Structure, Properties, Research Methods - Shendryk A.N. 2022

Peptide synthesis
Protection of the carboxyl group
Hydrazide group

The hydrazide group (-NH-NH2) as such is unsuitable for protecting the carboxyl function. In its presence, selective acylation of the amino group is impossible. Therefore, to obtain hydrazides, hydrazine derivatives are used (for example, benzyl or tert-butyloxy hydrazide), while the amino group in The amino acid is preliminarily blocked with a suitable N-protecting group (X):

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The hydrazide protecting group is removed by hydrogenolysis.



Last update: 06/08/2026

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