Principles of Biochemistry Volume 1 - A. Lehninger 1985

Biomolecules
Vitamins and Trace Elements: Their Role in Enzyme Function
Some oxidative enzymes also contain copper

Along with iron, the electron-transporting prosthetic groups of cytochrome c oxidase also contain copper, which plays a crucial role in the catalytic activity of this enzyme. Copper atoms in cytochrome c oxidase undergo cyclic valence changes between Cu (II) and Cu (I), thereby participating in electron transfer, with oxygen serving as the electron acceptor. Copper is also present in the Active Site of lysyl oxidase, an enzyme responsible for forming cross-links between The polypeptide chains of Collagen and Elastin (Sections 7.16 and 7.17). Copper deficiency in animals leads to The production of defective collagen lacking these cross-links. As a result, the collagen and elastin in the arterial walls become less robust, increasing the likelihood of rupture. Copper is also essential for the normal utilization of iron in The Human Body.



Last update: 06/08/2026

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