Principles of Protein Structural Organization - H. Schultz 1982

The structural role of the peptide bond
Conclusion

Peptide bonds are synthesized in a strictly controlled manner on Ribosomes. They can alter their configuration at a relatively low Free energy cost, helping the Organism rapidly adapt to environmental fluctuations. The rigidity of the peptide bond makes a significant contribution to protein stability. The Stability of the polypeptide chain is enhanced As a result of interactions between backbone atoms, as well as between backbone and side-chain atoms. The geometric conditions are satisfactorily described using potential energy maps, which can also account for backbone flexibility. The trans-peptide bond has clear advantages over the cis-bond, as it does not impose such severe structural constraints as the cis-bond.



Last update: 06/08/2026

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