Biochemistry - The Chemical Reactions of Living Cells, Volume 3 - D. Metzler 1980

Metabolism of Nitrogenous Compounds
Compounds Derived from Aspartate
Regulation of Biosynthetic Reactions from Aspartate

E. coli possesses three aspartokinases that catalyze The conversion of aspartate to $eta$-aspartyl phosphate. These three Enzymes catalyze the same reaction but differ significantly in their regulatory properties, as shown in Fig. 14-6. Each enzyme responds to a specific set of end products. The same applies to the two aspartate semialdehyde dehydrogenases that catalyze the third step. Note that both transcriptional repression and feedback inhibition of the enzymes themselves are observed here [48]. It should also be pointed out that many other regulatory factors could be added to the scheme depicted in Fig. 14-6.



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