Biochemistry - The Chemical Reactions of Living Cells Volume 2 - D. Metzler 1980

Types of reactions catalyzed by enzymes
Multiple displacement reactions and coupling of ATP cleavage reactions with endergonic processes
Conformational changes induced by phosphorylation

One of the possible outcomes of transferring a phosphate group to a functional group of a protein is the induction of a conformational change in the protein molecule. Indeed, there is compelling Evidence indicating the presence of such changes during the action of ATP-dependent ion pumps (Chap. 5, Sec. B,2,c) and in Muscle contraction (Addendum 10-E). Conformational changes may also result from the phosphorylation of protein regulatory sites. It is quite possible that the phosphorylation of an imidazole group hydrogen-bonded to the C = O group of the amide moiety in the polypeptide chain of a protein molecule leads to tautomeric transformations similar to the one given in equation (6-84). This may facilitate a conformational change or drive the protein into an "energy-rich" state capable of spontaneously altering its shape, as occurs During muscle contraction.



Last update: 06/08/2026

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