Human Biochemistry, Volume 1 - Murray R. 1993

Metabolism of Proteins and Amino Acids
Catabolism of Amino Acid Nitrogen
Regulation of Urea Synthesis

Functional interaction between Glutamate dehydrogenase and carbamoyl phosphate synthetase

Carbamoyl phosphate synthetase, together with mitochondrial glutamate dehydrogenase, directs the nitrogen of glutamate (and consequently of all Amino Acids in general, see Fig. 30.2) into carbamoyl phosphate and subsequently into urea. Although the Equilibrium Constant of the reaction catalyzed by glutamate dehydrogenase favors The formation of glutamate rather than ammonia, the removal of ammonia by carbamoyl phosphate synthetase and The oxidation of α-ketoglutarate in The Citric Acid Cycle promote the Catabolism of Glutamate.



Last update: 06/08/2026

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