Practical Protein Chemistry - A. Darbre 1989

Determination of C-Terminal Amino Acid Sequence
Conclusion

Successful determination of long C-terminal sequences still remains elusive. The Emergence of improved thiocyanate Cleavage techniques, novel approaches (the cyanamide method, Selective reduction, amino acid determination as aldehydes, alcoholysis of oxazoles) gives hope for the future development of a universal METHOD FOR DETERMINING extended sequences. However, many challenges must be overcome along this path. Those who undertake to solve this problem nowadays deserve admiration for their skill and courage, for many before them have tried to create a truly working method and failed [67a].



Last update: 06/08/2026

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