Textbook - BIOLOGICAL CHEMISTRY - Gubsky Yu.I. - 2000

PREFACE

INTRODUCTION. BIOCHEMISTRY AS A SCIENCE

Section I. BIOMOLECULES AND CELLULAR STRUCTURES

CHAPTER 1. BIOCHEMICAL COMPONENTS OF CELLS

CHAPTER 2. PROTEINS AND PEPTIDES

   2.1. BIOLOGICAL FUNCTIONS OF PROTEINS AND PEPTIDES

   2.2. STRUCTURE AND AMINO ACID COMPOSITION OF PROTEINS AND PEPTIDES

   2.3. LEVELS OF STRUCTURAL ORGANIZATION OF PROTEIN MOLECULES

   2.4. PHYSICOCHEMICAL PROPERTIES OF PROTEINS

   2.5. METHODS FOR ISOLATION AND ANALYSIS OF PROTEINS AND PEPTIDES

     2.5.1. Methods for protein isolation and fractionation

     2.5.2. Methods for determination of amino acid composition and primary structure of proteins and peptides

CHAPTER 3. NUCLEIC ACIDS. NUCLEOTIDES

   3.1. NUCLEOTIDES: STRUCTURE, BIOCHEMICAL FUNCTIONS

   3.2. NUCLEIC ACIDS: STRUCTURE, PROPERTIES

   3.3. STRUCTURE, PROPERTIES, AND BIOLOGICAL FUNCTIONS OF DNA

   3.4. STRUCTURE, PROPERTIES, AND BIOLOGICAL FUNCTIONS OF RNA

   3.5. MOLECULAR ORGANIZATION OF NUCLEAR CHROMATIN AND RIBOSOMES

CHAPTER 4. CARBOHYDRATES AND THEIR DERIVATIVES

   4.1. MONOSACCHARIDES AND THEIR DERIVATIVES

   4.2. COMPLEX CARBOHYDRATES. OLIGOSACCHARIDES. HOMOPOLYSACCHARIDES

   4.3. HETEROPOLYSACCHARIDES. PROTEOGLYCANS. GLYCOPROTEINS

   4.4. PEPTIDOGLYCANS OF MICROBIAL CELL WALLS

CHAPTER 5. LIPIDS. BIOMEMBRANES

   5.1. GENERAL CHARACTERISTICS OF LIPIDS. FATTY ACIDS

   5.2. STRUCTURE AND FUNCTIONS OF LIPIDS

   5.3. BIOLOGICAL MEMBRANES

Section II. GENERAL PRINCIPLES OF METABOLISM

CHAPTER 6. ENZYMES I. STRUCTURE AND PROPERTIES

   6.1. PROPERTIES OF ENZYMES AS BIOLOGICAL CATALYSTS

   6.2. NOMENCLATURE AND CLASSIFICATION OF ENZYMES

   6.3. CHEMICAL STRUCTURE OF ENZYMES. COENZYMES

CHAPTER 7. ENZYMES II. CATALYTIC MECHANISMS. KINETICS. REGULATION

   7.1. MECHANISMS OF ENZYME ACTION

   7.2. ENZYME KINETICS. ENZYME INHIBITORS

   7.3. REGULATION OF ENZYMATIC PROCESSES. ENZYMOPATHIES

CHAPTER 8. METABOLISM: CATABOLISM AND ANABOLISM

   8.1. GENERAL PRINCIPLES OF METABOLISM

   8.2. METHODS FOR STUDYING METABOLISM

   8.3. STAGES OF BIOMOLECULE CATABOLISM

CHAPTER 9. BIOENERGETIC PROCESSES: ELECTRON TRANSPORT; OXIDATIVE PHOSPHORYLATION IN MITOCHONDRIA

   9.1. REACTIONS OF BIOLOGICAL OXIDATION

   9.2. ENZYMES OF BIOLOGICAL OXIDATION

   9.3. MOLECULAR ORGANIZATION OF THE BIOLOGICAL OXIDATION CHAIN IN MITOCHONDRIA

   9.4. OXIDATIVE PHOSPHORYLATION AND MITOCHONDRIAL ATP SYNTHASE

   9.5. INHIBITORS OF ELECTRON TRANSPORT AND OXIDATIVE PHOSPHORYLATION IN MITOCHONDRIA

CHAPTER 10. TRICARBOXYLIC ACID CYCLE

   10.1. GENERAL CHARACTERISTICS OF THE TRICARBOXYLIC ACID CYCLE

   10.2. ENZYMATIC REACTIONS OF THE TRICARBOXYLIC ACID CYCLE

   10.3. ENERGY BALANCE OF THE TRICARBOXYLIC ACID CYCLE

   10.4. ANAPLEROTIC AND AMPHIBOLIC REACTIONS

Section III. METABOLISM OF MAJOR CLASSES OF BIOMOLECULES

CHAPTER 11. CARBOHYDRATE METABOLISM. I. AEROBIC AND ANAEROBIC GLUCOSE OXIDATION

   11.1. PATHWAYS OF INTRACELLULAR MONOSACCHARIDE CATABOLISM

   11.2. AEROBIC GLUCOSE OXIDATION

   11.3. GLYCOLYSIS: REACTIONS, ENERGETICS, REGULATION

   11.4. ENERGETICS OF GLYCOLYSIS AND AEROBIC GLUCOSE OXIDATION

CHAPTER 12. CARBOHYDRATE METABOLISM. II. ALTERNATIVE PATHWAYS OF MONOSACCHARIDE METABOLISM. REGULATION OF GLUCOSE METABOLISM

   12.1. PENTOSE PHOSPHATE PATHWAY OF GLUCOSE METABOLISM

   12.2. FRUCTOSE AND GALACTOSE METABOLISM

   12.3. GLUCOSE BIOSYNTHESIS AND ITS REGULATION

   12.4. REGULATION OF GLUCOSE METABOLISM. DIABETES MELLITUS

CHAPTER 13. CARBOHYDRATE METABOLISM. III. GLYCOGEN AND GLYCOCONJUGATE METABOLISM

   13.1. BIOSYNTHESIS AND DEGRADATION OF GLYCOGEN

   13.2. REGULATION OF GLYCOGENOLYSIS AND GLYCOGENESIS

   13.3. GENETIC DISORDERS OF GLYCOGEN METABOLISM

   13.4. METABOLISM OF CARBOHYDRATE MOIETIES IN GLYCOCONJUGATES

   13.5. GLYCOSIDASES. GENETIC DISORDERS OF GLYCOSAMINOGLYCAN METABOLISM

CHAPTER 14. LIPID METABOLISM. I. CATABOLISM OF TRIACYLGLYCEROLS AND FATTY ACIDS

   14.1. PATHWAYS OF LIPID METABOLISM

   14.2. CATABOLISM OF TRIACYLGLYCEROLS

   14.3. OXIDATION OF FATTY ACIDS AND GLYCEROL

   14.4. BIOSYNTHESIS AND CATABOLISM OF KETONE BODIES

CHAPTER 15. LIPID METABOLISM. II. BIOSYNTHESIS OF TRIACYLGLYCEROLS AND COMPLEX LIPIDS

   15.1. BIOSYNTHESIS OF HIGHER FATTY ACIDS

   15.2. BIOSYNTHESIS OF TRIACYLGLYCEROLS

   15.3. BIOSYNTHESIS OF PHOSPHOGLYCERIDES

   15.4. SPHINGOLIPID METABOLISM. SPHINGOLIPIDOSES

CHAPTER 16. LIPID METABOLISM. III. CHOLESTEROL METABOLISM. LIPID TRANSPORT

   16.1. CHOLESTEROL BIOSYNTHESIS

   16.2. BIOTRANSFORMATION OF CHOLESTEROL

   16.3. TRANSPORT AND STORAGE OF LIPIDS. PLASMA LIPOPROTEINS. HYPERLIPOPROTEINEMIAS

   16.4. PATHOLOGY OF LIPID METABOLISM: ATHEROSCLEROSIS, OBESITY, DIABETES MELLITUS

CHAPTER 17. AMINO ACID METABOLISM. I. GENERAL PATHWAYS OF TRANSFORMATION

   17.1. PATHWAYS OF AMINO ACID TRANSFORMATION IN TISSUES

   17.2. AMINO ACID TRANSAMINATION

   17.3. AMINO ACID DEAMINATION

   17.4. AMINO ACID DECARBOXYLATION

   17.5. AMMONIA METABOLISM. UREA BIOSYNTHESIS

CHAPTER 18. AMINO ACID METABOLISM. II. SPECIALIZED PATHWAYS OF METABOLISM

   18.1. METABOLIC PATHWAYS OF THE NITROGEN-FREE CARBON SKELETON OF AMINO ACIDS. GLUCOGENIC AND KETOGENIC AMINO ACIDS

   18.2. SPECIALIZED PATHWAYS OF ACYCLIC AMINO ACID METABOLISM

   18.3. SPECIALIZED PATHWAYS OF CYCLIC AMINO ACID METABOLISM

   18.4. PORPHYRIN METABOLISM

Section IV. MOLECULAR MECHANISMS OF HEREDITY AND GENETIC INFORMATION EXPRESSION

CHAPTER 19. NUCLEOTIDE BIOSYNTHESIS

   19.1. PURINE NUCLEOTIDE BIOSYNTHESIS

   19.2. PYRIMIDINE NUCLEOTIDE BIOSYNTHESIS

   19.3. DEOXYRIBONUCLEOTIDE BIOSYNTHESIS

   19.4. NUCLEOTIDE CATABOLISM

CHAPTER 20. MOLECULAR MECHANISMS OF DNA REPLICATION AND RNA TRANSCRIPTION

   20.1. BIOLOGICAL SIGNIFICANCE OF DNA REPLICATION. SEMICONSERVATIVE MECHANISM OF REPLICATION

   20.2. DNA REPLICATION ENZYMES IN PROKARYOTES AND EUKARYOTES

   20.3. MOLECULAR MECHANISMS OF DNA REPLICATION

   20.4. ENZYMES AND MECHANISMS OF RNA TRANSCRIPTION

CHAPTER 21. RIBOSOMAL PROTEIN BIOSYNTHESIS

   21.1. GENETIC CODE AND ITS PROPERTIES

   21.2. RIBOSOMAL PROTEIN-SYNTHESIZING SYSTEM

   21.3. STAGES AND MECHANISMS OF TRANSLATION

   21.4. REGULATION OF TRANSLATION. ANTIBIOTICS AS TRANSLATION INHIBITORS

CHAPTER 22. REGULATION OF GENE EXPRESSION. GENETIC RECOMBINATION

   22.1. REGULATION OF GENE EXPRESSION IN PROKARYOTES

   22.2. FEATURES OF MOLECULAR ORGANIZATION AND GENOME EXPRESSION IN EUKARYOTES

   22.3. MOLECULAR MECHANISMS OF MUTATIONS. DNA REPAIR

   22.4. GENETIC ENGINEERING. RECOMBINANT DNA

Section V. HORMONES IN THE SYSTEM OF INTERCELLULAR INTEGRATION OF BODY FUNCTIONS

CHAPTER 23. HORMONAL REGULATION OF METABOLISM AND CELLULAR BIOLOGICAL FUNCTIONS. I. BIOCHEMICAL SYSTEMS OF INTRACELLULAR TRANSDUCTION OF HORMONAL SIGNALS

   23.1. HORMONES AND BIOREGULATORS: DEFINITION, CLASSIFICATION

   23.2. MOLECULAR AND CELLULAR MECHANISMS OF PEPTIDE HORMONE AND BIOGENIC AMINE ACTION

   23.3. MOLECULAR AND CELLULAR MECHANISMS OF STEROID AND THYROID HORMONE ACTION

CHAPTER 24. HORMONAL REGULATION OF METABOLISM AND CELLULAR BIOLOGICAL FUNCTIONS. II. HORMONES DERIVED FROM PEPTIDES AND AMINO ACIDS

   24.1. HYPOTHALAMIC-PITUITARY SYSTEM

   24.2. HORMONES OF THE PANCREAS AND GASTROINTESTINAL TRACT

   24.3. THYROID HORMONES

   24.4. CATECHOLAMINES AND OTHER BIOGENIC AMINES

CHAPTER 25. HORMONAL REGULATION OF METABOLISM AND CELLULAR BIOLOGICAL FUNCTIONS. III. HORMONES AND OTHER LIPID-DERIVED BIOREGULATORS

   25.1. GENERAL CHARACTERISTICS OF STEROID HORMONES

   25.2. ADRENAL CORTEX STEROID HORMONES

   25.3. SEX HORMONES

   25.4. HORMONAL REGULATORS OF CALCIUM HOMEOSTASIS

   25.5. PHYSIOLOGICALLY ACTIVE EICOSANOIDS

Section VI. BIOCHEMISTRY OF PHYSIOLOGICAL FUNCTIONS AND SPECIALIZED TISSUES

CHAPTER 26. HUMAN NUTRITIONAL BIOCHEMISTRY. I. NUTRIENTS. DIGESTION OF NUTRIENTS

   26.1. COMPONENTS OF A NORMAL HUMAN DIET

   26.2. HUMAN NUTRIENT REQUIREMENTS

   26.3. MECHANISMS OF NUTRIENT TRANSFORMATION IN THE GASTROINTESTINAL TRACT

CHAPTER 27. HUMAN NUTRITIONAL BIOCHEMISTRY. II. VITAMINS AS DIETARY COMPONENTS

   27.1. VITAMINS AS COMPONENTS OF HUMAN NUTRITION; VITAMIN DEFICIENCY DISEASES

   27.2. COENZYME VITAMINS. ASCORBIC ACID AND BIOFLAVONOIDS

   27.3. FAT-SOLUBLE VITAMINS. BIOANTIOXIDANTS

CHAPTER 28. BIOCHEMISTRY AND PATHOBIOCHEMISTRY OF BLOOD

   28.1. PHYSIOLOGICAL AND BIOCHEMICAL FUNCTIONS OF BLOOD

   28.2. RESPIRATORY FUNCTION OF ERYTHROCYTES. BIOCHEMISTRY AND PATHOBIOCHEMISTRY OF HEMOGLOBIN

   28.3. ACID-BASE BALANCE. BLOOD BUFFER SYSTEMS

   28.4. BIOCHEMICAL COMPOSITION OF BLOOD IN HEALTH AND DISEASE

CHAPTER 29. BIOCHEMISTRY OF THE BLOOD COAGULATION AND FIBRINOLYTIC SYSTEMS

   29.1. FUNCTIONAL AND BIOCHEMICAL PROPERTIES OF THE HEMostatic SYSTEM

   29.2. BLOOD COAGULATION SYSTEM: COMPONENTS, ACTIVATION MECHANISMS

   29.3. ANTICOAGULANT SYSTEM OF BLOOD

   29.4. BLOOD FIBRINOLYTIC SYSTEM

CHAPTER 30. BIOCHEMISTRY OF IMMUNE PROCESSES

   30.1. CELLULAR AND BIOCHEMICAL ORGANIZATION OF THE IMMUNE SYSTEM

   30.2. IMMUNOGLOBULINS: STRUCTURE AND BIOLOGICAL FUNCTIONS

   30.3. MEDIATORS AND HORMONES OF THE IMMUNE SYSTEM

   30.4. BIOCHEMICAL COMPONENTS OF THE COMPLEMENT SYSTEM

   30.5. BIOCHEMICAL MECHANISMS OF IMMUNODEFICIENCY STATES

CHAPTER 31. BIOCHEMICAL FUNCTIONS OF THE LIVER. DETOXIFICATION PROCESSES

   31.1. STRUCTURAL AND FUNCTIONAL ORGANIZATION OF THE LIVER. BIOCHEMICAL FUNCTIONS OF HEPATOCYTES

   31.2. BIOTRANSFORMATION OF XENOBIOTICS AND ENDOGENOUS TOXINS. MICROSOMAL OXIDATION

   31.3. METABOLISM OF BILE PIGMENTS. BIOCHEMISTRY OF JAUNDICE

CHAPTER 32. BIOCHEMISTRY OF MUSCLES AND MUSCLE CONTRACTION

   32.1. ULTRASTRUCTURE AND CHEMICAL COMPOSITION OF MUSCLES

   32.2. MOLECULAR MECHANISMS OF MUSCLE CONTRACTION

   32.3. BIOENERGETICS OF MUSCLE TISSUE

CHAPTER 33. BIOCHEMISTRY OF THE NERVOUS SYSTEM. MOLECULAR PSYCHOBIOLOGY

   33.1. FEATURES OF CHEMICAL COMPOSITION AND METABOLISM OF THE NERVOUS SYSTEM

   33.2. NEUROTRANSMITTERS. RECEPTORS FOR NEUROTRANSMITTERS AND PHYSIOLOGICALLY ACTIVE COMPOUNDS

   33.3. NEUROCHEMICAL MECHANISMS OF ACTION OF PSYCHOTROPIC AGENTS

REFERENCES