Protein Structure and Function: Application of Bioinformatics Methods - John Rigden 2014

Bioinformatics Methods for Studying the Structure and Function of Disordered Proteins
Functional Classification of IDPs

Predicting the Functions of IDPs is a significantly more complex task than predicting their structures, for several reasons. First of all, IDPs evolve very rapidly, and while their core structural states often remain unchanged, very little is known about The Nature and scale of functional changes. Another reason is that the Structure/81.html">Functional Classification of Proteins/genes is usually carried out at the whole-Gene level, and it is often completely unclear how and to what extent this process is influenced by disorder-based regions (DBRs). In addition, in many cases, IDP functions cannot be accommodated within the functional classification schemes developed for ordered proteins. The field of IDP functional classification is currently undergoing active development, which has so far led to The Emergence of two fundamentally different classification approaches. Their key aspects are discussed below.



Last update: 06/08/2026

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