Biochemistry - Chemical Reactions in Living Cells, Volume 1 - D. Metzler 1980

Bioenergetics of Biochemical Reactions
Thermodynamics
Effect of Temperature on Equilibrium

At constant pressure, ∆G changes with Temperature According to the following equation:

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The corresponding changes in K are described by the van 't Hoff equation

If ∆H0 can be assumed constant over the temperature range of the experiment, a plot of lnC versus 1/T makes it possible to determine ∆H0 (or ∆H' if the plot is constructed for lnK'): the slope of the line is equal to —∆H0/R. Since knowing K allows one to calculate ∆G0, equation (3-14) can then be used to determine ∆S0. However, this method yields low accuracy, and therefore it is preferable to measure ∆H directly by calorimetry. Moreover, the assumption that ∆H0 remains constant over a wide temperature range, particularly for Proteins, may prove to be incorrect.



Last update: 06/08/2026

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