Human Biochemistry, Volume 2 - Murray R. 1993

Special Topics
Glycoproteins and Proteoglycans
Glycoproteins – Secretory Locus

The secretory locus (Se) encodes a specific fucosyltransferase in secretory Organs, such as exocrine glands, but not in erythrocytes. Accordingly, for example, individuals with the SeSe or Sese genotype will synthesize the precursor of A and B Antigens in their salivary exocrine glands, and in the presence of specific A or B transferases, they will secrete A or B antigens (or both) (Table 54.8). Individuals with the sese genotype will not secrete A or B antigens; however, if the H allele and A or B alleles are present, their erythrocytes will be able to express A, B, or both antigens.



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