Human Biochemistry, Volume 1 - Murray R. 1993

Structure and Functions of Proteins and Enzymes
Enzymes: Kinetics
Free Energy Changes Associated with Transition State Formation and Decay

The principles formulated above are illustrated graphically in Figs. 8.1 and 8.2, which show reaction profiles depicting the relationship between ∆G, ∆GF, and ∆GD. Note that ∆G is negative in Fig. 8.1 (∆G<0) and positive in Fig. 8.2 (∆G>0); nevertheless, in both cases, ∆GF is positive (∆GF>0) and ∆GD is negative (∆GD<0). Therefore, as noted above, the sign and magnitude of ∆G do not yet provide any indication of the sign and magnitude of ∆GF or ∆GD.



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