Intensive Care of Acute Poisoning - A. V. Hovenko 2010

Methods of Detoxification Therapy
Methods for Stimulating Natural Detoxification
Therapeutic Pulmonary Hyperventilation

Therapeutic hyperventilation is among the Methods used to enhance the body's natural detoxification processes. It can be achieved by placing the patient on mechanical ventilation, which allows a 1.5-to-2-fold increase in minute ventilation. This method is most effective in acute poisonings with toxic substances that are eliminated from the body primarily via the Lungs.

Therapeutic hyperventilation is highly effective in acute poisonings with hydrogen sulfide (up to 70% of it is excreted through the lungs), chlorinated Hydrocarbons, and carbon monoxide.

However, prolonged hyperventilation can lead to disturbances in Blood gas composition (hypocapnia) and acid-base balance (respiratory alkalosis). Therefore, intermittent hyperventilation (15–20 minutes at a time) is typically performed repeatedly every 1–2 hours throughout the toxicogenic phase of poisoning, under the monitoring of blood gas parameters.



Last update: 08/08/2026

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