Protein Structure and Function. Application of Bioinformatics Methods - John Rigden 2014

Bioinformatics methods for studying the structure and function of disordered proteins
Disorder prediction
Prediction of low-complexity regions

As shown in the studies mentioned above, Structure/70.html">Low Sequence Complexity differs from disorder, although predicting low-complexity regions can be viewed as a first rational approach to assessing disorder, or at least a lack of globularity. The Shannon Entropy function (Shannon 1948), adapted for protein sequences (Wootton 1994a, b), forms The basis of the SEG program, which is commonly used to identify compositional low-complexity segments whose sequences are prone to forming disordered regions. This Procedure is of great importance in detecting non-globular protein regions.



Last update: 06/08/2026

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